Biochemical Evaluation of Serum Lipid Profile and Serum Uric Acid in Preeclampsia: A Case- Control Study

Introduction/Background: Preeclampsia is a pregnancy specific, multisystem disorder characterized by various biochemical abnormalities. Dyslipidemia and Hyperuricemia have been shown to play a significant role in the pathogenesis of the disease and often precede clinical manifestations. Objectives: To evaluate Serum lipid profile and uric acid in preeclampsia subjects and to determine if there is any change in these parameters as compared tonormal pregnant women. Materials and Methods:In our study we have included 35 Preeclampsia and 35 Normal pregnant women. Serum lipid profile and uric acid were estimated by standard methods. Results:We observedsignificantly increased Serum uric acid and Triglyceride levels (p<0.001 and p<0.05 respectively) in preeclampsia group compared to control group. Total cholesterol and LDL-C was increased and HDL-C was decreased in preeclampsia group as compared to normal pregnant group but the results were not statistically significant. Conclusion: Measurement of blood lipids and uric acid may be helpful in early diagnosis and prevention of maternal and fetal complications in preeclampsia.